The effects of Carnosine on High Glucose-Induced Apoptosis of Human Umbilical Vein Endothelial Cells

被引:1
作者
Shi, Yan [1 ]
Zhang, Chunjing [1 ]
机构
[1] Qiqihar Med Univ, Dept Biochem & Mol Biol, Qiqihar 161006, Heilongjiang Pr, Peoples R China
来源
SMART MATERIALS AND NANOTECHNOLOGY IN ENGINEERING | 2012年 / 345卷
关键词
High glucose; oxidative stress; carnosine; apoptosis;
D O I
10.4028/www.scientific.net/AMR.345.365
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Purposes,To explore the effects of carnosine on high glucose-induced apoptosis of human umbilical vein endothelial cells (HUVECs). Methods HUVECs were cultured in vitro. The cellular apoptotic model was made by the addition of high glucose (25 mmol/L), the group of high glucose and carnosine was administered by the addition of high glucose (25 mmol/L) with carnosine (20 mmol/L). In addition, cell apoptosis was detected by the electron microscopy and AnnexinV/PI flow cytometry. Results Compared with the control group, high glucose could induce HUVECs apoptosis under electron microscopy and AnnexinV/PI flow cytometry, while 20 mmol/L carnosine could inhibit the apoptosis induced by high glucose significantly (##P < 0.05). Conclusion In this study, carnosine could inhibit high-glucose induced apoptosis of human umbilical vein endothelial cells.
引用
收藏
页码:365 / 369
页数:5
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