The potential of nitric oxide releasing therapies as antimicrobial agents

被引：425
作者：
Schairer, David O.
Chouake, Jason S.
Nosanchuk, Joshua D. [2 ,3 ]
Friedman, Adam J. [1 ,4 ]
机构：
[1] Albert Einstein Coll Med, Dept Med, Div Dermatol, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Dept Med, Div Infect Dis, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA
[4] Albert Einstein Coll Med, Dept Physiol Biophys, Bronx, NY 10467 USA
来源：
VIRULENCE | 2012年 / 3卷 / 03期
关键词：
nitric oxide; nanotechnology; antimicrobial; antibiotic; STAPHYLOCOCCUS-AUREUS; ACIDIFIED NITRITE; IN-VITRO; BACTERICIDAL ACTIVITY; GLYCERYL TRINITRATE; CHEMICAL BIOLOGY; REACTIVE OXYGEN; NANOPARTICLES; NO; EFFICACY;
D O I：
10.4161/viru.20328
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nitric oxide (NO) is a short-lived, diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.
引用
收藏
页码：271 / 279
页数：9
相关论文
共 106 条
[1]   PEPTIDE-TRANSPORT AND CHEMOTAXIS IN ESCHERICHIA-COLI AND SALMONELLA-TYPHIMURIUM - CHARACTERIZATION OF THE DIPEPTIDE PERMEASE (DPP) AND THE DIPEPTIDE-BINDING PROTEIN [J].
ABOUHAMAD, WN ;
MANSON, M ;
GIBSON, MM ;
HIGGINS, CF .
MOLECULAR MICROBIOLOGY, 1991, 5 (05) :1035-1047
[2]   Evolution of the Nitric Oxide Synthase Family in Metazoans [J].
Andreakis, Nikos ;
D'Aniello, Salvatore ;
Albalat, Ricard ;
Patti, Francesco Paolo ;
Garcia-Fernandez, Jordi ;
Procaccini, Gabriele ;
Sordino, Paolo ;
Palumbo, Anna .
MOLECULAR BIOLOGY AND EVOLUTION, 2011, 28 (01) :163-179
[3]   Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States [J].
Angus, DC ;
Clermont, G ;
Watson, RS ;
Linde-Zwirble, WT ;
Clark, RH ;
Roberts, MS .
PEDIATRICS, 2003, 112 (06) :1351-1360
[4]   Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms [J].
Barraud, Nicolas ;
Storey, Michael V. ;
Moore, Zoe P. ;
Webb, Jeremy S. ;
Rice, Scott A. ;
Kjelleberg, Staffan .
MICROBIAL BIOTECHNOLOGY, 2009, 2 (03) :370-378
[5]  
Bátai I, 1999, ANESTH ANALG, V89, P1570
[6]  
Bhide M., 2006, Nitric Oxide Delivery From Polymeric Wound Dressings
[7]   Intragastric generation of antimicrobial nitrogen oxides from saliva -: Physiological and therapeutic considerations [J].
Bjorne, Hakan ;
Weitzberg, Eddie ;
Lundberg, Jon O. .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (09) :1404-1412
[8]   Nitric oxide and the immune response [J].
Bogdan, C .
NATURE IMMUNOLOGY, 2001, 2 (10) :907-916
[9]  
Bogdan C, 2011, METHODS MOL BIOL, V677, P375, DOI 10.1007/978-1-60761-869-0_24
[10]   Cellular targets and mechanisms of nitros(yl)ation:: An insight into their nature and kinetics in vivo [J].
Bryan, NS ;
Rassaf, T ;
Maloney, RE ;
Rodriguez, CM ;
Saijo, F ;
Rodriguez, JR ;
Feelisch, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (12) :4308-4313
12345678910