New insights into the function of granulomas in human tuberculosis

被引：289
作者：
Ulrichs, T [1 ]
Kaufmann, SHE [1 ]
机构：
[1] Max Planck Inst Infect Biol, Dept Immunol, D-10117 Berlin, Germany
来源：
JOURNAL OF PATHOLOGY | 2006年 / 208卷 / 02期
关键词：
tuberculosis; granuloma; immune response; Mycobacterium tuberculosis;
D O I：
10.1002/path.1906
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The human tuberculous granuloma provides the morphological framework for local immune processes central to the outcome of tuberculosis. This review article describes investigations on human lung granulomas aimed at better understanding the regional host response and counter-measures to Mycobacterium tuberculosis. These findings lead to a revised view of the regional immune response in human tuberculosis. Novel insights into this dynamic cross-talk form the basis of novel intervention strategies. Copyright (c) 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
引用
收藏
页码：261 / 269
页数：9
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