Design and Synthesis of Polycyclic Imidazole-Containing N- Heterocycles based on C?H Activation/Cyclization Reactions

被引:33
作者
Iaroshenko, Viktor O. [1 ,2 ]
Ostrovskyi, Dmytro [1 ]
Miliutina, Mariia [1 ]
Maalik, Aneela [1 ]
Villinger, Alexander [1 ]
Tolmachev, Andrei [2 ,3 ]
Volochnyuk, Dmitriy M. [3 ,4 ]
Langer, Peter [1 ,5 ]
机构
[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
[2] Natl Taras Shevchenko Univ, UA-01033 Kiev 33, Ukraine
[3] Enamine Ltd, UA-01103 Kiev, Ukraine
[4] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev 94, Ukraine
[5] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
关键词
C?H activation; cyclization; fluorine; imidazoles; palladium; CATALYZED DIRECT ARYLATION; H BOND ACTIVATION; PRIVILEGED STRUCTURES; BENZOIC-ACIDS; REGIOSELECTIVE SYNTHESIS; CYTOSTATIC ACTIVITY; DIRECT ALKYLATION; PALLADIUM; ALKYNES; FUNCTIONALIZATION;
D O I
10.1002/adsc.201200221
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A new strategy for the synthesis of polycyclic imidazole-containing N-heterocycles, based on the two general synthetic ways, namely the Pd(II)-catalyzed intramolecular arylation via CH/C?Hal and CH/CH coupling reactions, was developed. The method proposed here enables the synthesis of many fused N-heterocycles containing purine, 1-deazapurines and benzimidazole structural units.
引用
收藏
页码:2495 / 2503
页数:9
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