Current Trends in Fabrication of Biomaterials for Bone and Cartilage Regeneration: Materials Modifications and Biophysical Stimulations

被引：85

作者：

Przekora, Agata ^{[1
]}

机构：

[1] Med Univ Lublin, Chair & Dept Biochem & Biotechnol, W Chodzki 1 St, PL-20093 Lublin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 02期

关键词：

metal ion substitution; antibacterial biomaterials; hydroxyapatite; atmospheric pressure plasma; magnetic field; low-intensity pulsed ultrasound; piezoelectric biomaterials; BIOACTIVE GLASS SCAFFOLDS; MESENCHYMAL STEM-CELLS; STATIC MAGNETIC-FIELD; POLYLACTIC ACID PLA; SURFACE MODIFICATION; OSTEOBLAST DIFFERENTIATION; SUBSTITUTED HYDROXYAPATITE; OSTEOGENIC DIFFERENTIATION; ANTIBACTERIAL PROPERTIES; ANTIMICROBIAL ACTIVITY;

D O I：

10.3390/ijms20020435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of engineering of biomaterials is to fabricate implantable biocompatible scaffold that would accelerate regeneration of the tissue and ideally protect the wound against biodevice-related infections, which may cause prolonged inflammation and biomaterial failure. To obtain antimicrobial and highly biocompatible scaffolds promoting cell adhesion and growth, materials scientists are still searching for novel modifications of biomaterials. This review presents current trends in the field of engineering of biomaterials concerning application of various modifications and biophysical stimulation of scaffolds to obtain implants allowing for fast regeneration process of bone and cartilage as well as providing long-lasting antimicrobial protection at the site of injury. The article describes metal ion and plasma modifications of biomaterials as well as post-surgery external stimulations of implants with ultrasound and magnetic field, providing accelerated regeneration process. Finally, the review summarizes recent findings concerning the use of piezoelectric biomaterials in regenerative medicine.

引用

页数：17

共 124 条

[1] 3D plotting of growth factor loaded calcium phosphate cement scaffolds [J].

Akkineni, Ashwini Rahul ;

Luo, Yongxiang ;

Schumacher, Matthias ;

Nies, Berthold ;

Lode, Anja ;

Gelinsky, Michael .

ACTA BIOMATERIALIA, 2015, 27 :264-274

[2] Effects of scaffold microstructure and low intensity pulsed ultrasound on chondrogenic differentiation of human mesenchymal stem cells [J].

Aliabouzar, Mitra ;

Lee, Se-jun ;

Zhou, Xuan ;

Zhang, Grace Lijjie ;

Sarkar, Kausik .

BIOTECHNOLOGY AND BIOENGINEERING, 2018, 115 (02) :495-506

[3] Lipid Coated Microbubbles and Low Intensity Pulsed Ultrasound Enhance Chondrogenesis of Human Mesenchymal Stem Cells in 3D Printed Scaffolds [J].

Aliabouzar, Mitra ;

Zhang, Lijie Grace ;

Sarkar, Kausik .

SCIENTIFIC REPORTS, 2016, 6

[4] Super-paramagnetic responsive silk fibroin/chitosan/magnetite scaffolds with tunable pore structures for bone tissue engineering applications [J].

Aliramaji, Shamsa ;

Zamanian, Ali ;

Mozafari, Masoud .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 70 :736-744

[5] Metallic Scaffolds for Bone Regeneration [J].

Alvarez, Kelly ;

Nakajima, Hideo .

MATERIALS, 2009, 2 (03) :790-832

[6] Long-term evaluation of the degradation behavior of three apatite-forming calcium phosphate cements [J].

An, Jie ;

Liao, Hongbing ;

Kucko, Nathan W. ;

Herber, Ralf-Peter ;

Wolke, Joop G. C. ;

van den Beucken, Jeroen J. J. P. ;

Jansen, John A. ;

Leeuwenburgh, Sander C. G. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2016, 104 (05) :1072-1081

[7] Accelerated bone ingrowth by local delivery of strontium from surface functionalized titanium implants [J].

Andersen, Ole Z. ;

Offermanns, Vincent ;

Sillassen, Michael ;

Almtoft, Klaus P. ;

Andersen, Inge H. ;

Sorensen, Soren ;

Jeppesen, Christian S. ;

Kraft, David C. E. ;

Bottiger, Jorgen ;

Rasse, Michael ;

Kloss, Frank ;

Foss, Morten .

BIOMATERIALS, 2013, 34 (24) :5883-5890

[8] Preparation and characterization of novel sol-gel derived hydroxyapatite/Fe3O4 composites coatings on Ti-6Al-4V for biomedical applications [J].

Anjaneyulu, U. ;

Vijayalakshmi, U. .

MATERIALS LETTERS, 2017, 189 :118-121

[9]

[Anonymous], 2016, BIOSURF BIOTRIBOL, DOI [10.1016/j.bsbt.2016.02.004, DOI 10.1016/j.bsbt.2016.02.004, DOI 10.1016/J.BSBT.2016.02.004]

[10]

[Anonymous], 2017, NANOTECHNOLOGY TISSU

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