Development of docetaxel-loaded PEG-PLA nanoparticles using surfactant-free method for controlled release studies

被引：5
|
作者：
Mishra, Prajna [1 ]
Dey, Ratan Kumar [1 ]
机构：
[1] Cent Univ Jharkhand, Ctr Appl Chem, Ranchi 835205, Bihar, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 09期
关键词：
Drug delivery systems; micelles; nanoparticles; PEG-PLA; TARGETED DRUG-DELIVERY; IN-VITRO EVALUATION; COPOLYMER NANOPARTICLES; POLYMERIC MICELLES; P-GLYCOPROTEIN; CLINICAL-TRIAL; PHASE-II; CANCER; FORMULATION;
D O I：
10.1080/00914037.2017.1354193
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Docetaxel (DTX)-loaded poly(ethylene glycol)-poly(D,L-lactide) is prepared by nanoprecipitation method in the absence of any surfactants. The average particle size of the copolymer was found to be 101nm. The drug entrapment efficiency (%) and drug loading (%) of polymer were found to be 9.471 +/- 0.047 and 94.71 +/- 0.466, respectively. The in vitro drug release characteristics show the controlled release of 98% of docetaxel in 72h. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and apoptosis measured in terms of cleaved Poly(ADP-ribose) Polymerase (PARP) and cleaved caspase-3 protein expression shows that the copolymer has better cytotoxicity effect and apoptosis in comparison to free DTX in HeLa cells. [GRAPHICS]
引用
收藏
页码：535 / 542
页数：8
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