Rational vaccinology with spherical nucleic acids

被引:95
作者
Wang, Shuya [1 ]
Qin, Lei [2 ]
Yamankurt, Gokay [1 ]
Skakuj, Kacper [3 ]
Huang, Ziyin [4 ]
Chen, Peng-Cheng [4 ]
Dominguez, Donye [2 ]
Lee, Andrew [5 ]
Zhang, Bin [2 ]
Mirkin, Chad A. [3 ,6 ]
机构
[1] Northwestern Univ, Interdisciplinary Biol Sci Grad Program, Evanston, IL 60208 USA
[2] Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA
[4] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
[5] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA
[6] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA
基金
美国国家卫生研究院;
关键词
spherical nucleic acids; cancer vaccinology; structural design; nanotechnology; immunotherapy; CELL-ACTIVATION; NANOPARTICLES; DELIVERY; THERAPEUTICS; NANOCARRIERS; BIOMATERIALS; ANTI-CTLA-4; ANTI-PD-1; VACCINES; SAFETY;
D O I
10.1073/pnas.1902805116
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the case of cancer immunotherapy, nanostructures are attractive because they can carry all of the necessary components of a vaccine, including both antigen and adjuvant. Herein, we explore how spherical nucleic acids (SNAs), an emerging class of nanotherapeutic materials, can be used to deliver peptide antigens and nucleic acid adjuvants to raise immune responses that kill cancer cells, reduce (or eliminate) tumor growth, and extend life in three established mouse tumor models. Three SNA structures that are compositionally nearly identical but structurally different markedly vary in their abilities to cross-prime antigen-specific CD8(+) T cells and raise subsequent antitumor immune responses. Importantly, the most effective structure is the one that exhibits synchronization of maximum antigen presentation and costimulatory marker expression. In the human papillomavirus-associated TC-1 model, vaccination with this structure improved overall survival, induced the complete elimination of tumors from 30% of the mice, and conferred curative protection from tumor rechallenges, consistent with immunological memory not otherwise achievable. The antitumor effect of SNA vaccination is dependent on the method of antigen incorporation within the SNA structure, underscoring the modularity of this class of nanostructures and the potential for the deliberate design of new vaccines, thereby defining a type of rational cancer vaccinology.
引用
收藏
页码:10473 / 10481
页数:9
相关论文
共 40 条
[1]  
[Anonymous], 2015, ASCO M ABSTRACTS S15
[2]  
[Anonymous], 2015, ASCO M
[3]  
Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/NMAT2992, 10.1038/nmat2992]
[4]  
Bakker ABH, 1996, THESIS
[5]   Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination [J].
Boutros, Celine ;
Tarhini, Ahmad ;
Routier, Emilie ;
Lambotte, Olivier ;
Ladurie, Francois Leroy ;
Carbonnel, Franck ;
Izzeddine, Hassane ;
Marabelle, Aurelien ;
Champiat, Stephane ;
Berdelou, Armandine ;
Lanoy, Emilie ;
Texier, Matthieu ;
Libenciuc, Cristina ;
Eggermont, Alexander M. M. ;
Soria, Jean-Charles ;
Mateus, Christine ;
Robert, Caroline .
NATURE REVIEWS CLINICAL ONCOLOGY, 2016, 13 (08) :473-486
[6]   Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell-Dependent Mechanism [J].
Chen, Siqi ;
Wang, Long ;
Fan, Jie ;
Ye, Cong ;
Dominguez, Donye ;
Zhang, Yi ;
Curiel, Tyler J. ;
Fang, Deyu ;
Kuzel, Timothy M. ;
Zhang, Bin .
CANCER RESEARCH, 2015, 75 (03) :519-531
[7]   Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy [J].
Coulie, Pierre G. ;
Van den Eynde, Benoit J. ;
van der Bruggen, Pierre ;
Boon, Thierry .
NATURE REVIEWS CANCER, 2014, 14 (02) :135-146
[8]   Nanoparticles in drug delivery: Past, present and future [J].
Couvreur, P. .
ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :21-23
[9]   Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer [J].
Dominguez, Donye ;
Ye, Cong ;
Geng, Zhe ;
Chen, Siqi ;
Fan, Jie ;
Qin, Lei ;
Long, Alan ;
Wang, Long ;
Zhang, Zhuoli ;
Zhang, Yi ;
Fang, Deyu ;
Kuzel, Timothy M. ;
Zhang, Bin .
JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :1365-1375
[10]   Bionanotechnology for vaccine design [J].
Frey, Steven ;
Castro, Ana ;
Arsiwala, Ammar ;
Kane, Ravi S. .
CURRENT OPINION IN BIOTECHNOLOGY, 2018, 52 :80-88