Hematopoietic stem cell transplantation using umbilical cord blood progenitors:: review of current clinical results

被引:67
作者
Benito, AI
Diaz, MA
González-Vicent, M
Sevilla, J
Madero, L
机构
[1] Univ Autonoma Madrid, Nino Jesus Childrens Hosp, Dept Hematol Oncol, Madrid 28009, Spain
[2] Univ Autonoma Madrid, Nino Jesus Childrens Hosp, Bone Marrow Transplantat Unit, Madrid, Spain
关键词
umbilical cord blood; UCB; children; transplantation; hematopoieteic transplant;
D O I
10.1038/sj.bmt.1704405
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Umbilical cord blood ( CB) has been rapidly established as an alternative source of stem cells to bone marrow for allogeneic- related and unrelated hematopoietic transplantation. To date, almost 70 000 CB units are available for transplantation and more than 2000 CB transplants ( CBT) have been performed, mostly in children, for the treatment of a variety of malignant and nonmalignant conditions. Consider able experience has been rapidly accumulated in this field and many aspects of CBT have been elucidated, while other questions remain unresolved. A concise review of the clinical results achieved after related and unrelated CBT is presented and discussed.
引用
收藏
页码:675 / 690
页数:16
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