Functionalisation of nonactivated bonds in superacidic media.

Ionization of non activated carbon-hydrogen bonds in functionalized compounds can be carried out in superacids by protolysis or by electrophiles (superelectrophiles): protonated ozone O3H+, protnated hydrogen peroxide H3O2+, trichloromethyl cation CCl3+. On account of the electrophilic nature of the reagent, reaction occurs at a carbon atom far from the protonated functional group and results, according to the trapping conditions, by oxyfunctionalization, fluoration, arylation, carboxylation or dehydrogenation of the substrate. Functionalization of carbon-hydrogen bonds far from the functional group can also be carried out by generating alpha-acylcarbenium ions, the resulting ions isomerizing to more stable isomers.