Organocatalytic Asymmetric Synthesis of Tetracyclic Pyridocarbazole Derivatives by Using a Diels-Alder/aza-Michael/Aldol Condensation Domino Reaction

被引：75
作者：
Enders, Dieter [1 ]
Joie, Celine [1 ]
Deckers, Kristina [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 33期
关键词：
asymmetric synthesis; domino reactions; organocatalysis; pyridocarbazoles; triple cascade; DIARYLPROLINOL SILYL ETHER; CASCADE REACTIONS; NATURAL-PRODUCTS; CHEMISTRY; ECONOMY; TETRAHYDROCARBAZOLES; 3-VINYLINDOLES; CONSTRUCTION; CATALYSIS;
D O I：
10.1002/chem.201302127
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Triple domino: An organocatalytic asymmetric triple cascade reaction to form tetracyclic pyridocarbazole derivatives is described. The new protocol includes a Diels-Alder/aza-Michael/aldol condensation sequence. Up to six stereogenic centers are formed with excellent diastereo- and enantioselectivity. IM = iminium activation; EN = enamine activation. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：10818 / 10821
页数：4
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