Autophagosome Formation: Tracing the Source

被引：48

作者：

Bernard, Amelie ^{[1
]}

Klionsky, Daniel J. ^{[1
]}

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

来源：

DEVELOPMENTAL CELL | 2013年 / 25卷 / 02期

关键词：

D O I：

10.1016/j.devcel.2013.04.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-mitochondria contact sites are involved in phagophore assembly.

引用

收藏

页码：116 / 117

页数：2

相关论文

共 7 条

[1] Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[2] Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation [J].

Hailey, Dale W. ;

Rambold, Angelika S. ;

Satpute-Krishnan, Prasanna ;

Mitra, Kasturi ;

Sougrat, Rachid ;

Kim, Peter K. ;

Lippincott-Schwartz, Jennifer .

CELL, 2010, 141 (04) :656-667

[3] Autophagosomes form at ER-mitochondria contact sites [J].

Hamasaki, Maho ;

Furuta, Nobumichi ;

Matsuda, Atsushi ;

Nezu, Akiko ;

Yamamoto, Akitsugu ;

Fujita, Naonobu ;

Oomori, Hiroko ;

Noda, Takeshi ;

Haraguchi, Tokuko ;

Hiraoka, Yasushi ;

Amano, Atsuo ;

Yoshimori, Tamotsu .

NATURE, 2013, 495 (7441) :389-393

[4] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation [J].

Hayashi-Nishino, Mitsuko ;

Fujita, Naonobu ;

Noda, Takeshi ;

Yamaguchi, Akihito ;

Yoshimori, Tamotsu ;

Yamamoto, Akitsugu .

NATURE CELL BIOLOGY, 2009, 11 (12) :1433-U102

[5] The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes [J].

Itakura, Eisuke ;

Kishi-Itakura, Chieko ;

Mizushima, Noboru .

CELL, 2012, 151 (06) :1256-1269

[6]

Mari Muriel, 2011, F1000 Biol Rep, V3, P25, DOI 10.3410/B3-25

[7] Endoplasmic reticulum-mitochondria contacts: function of the junction [J].

Rowland, Ashley A. ;

Voeltz, Gia K. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (10) :607-615