Evaluation of markers of inflammation, insulin resistance and endothelial dysfunction in children at risk for overweight

被引:28
作者
Akinci, Gulcin
Akinci, Baris [1 ]
Coskun, Senol [2 ]
Bayindir, Petek [3 ]
Hekimsoy, Zeliha [4 ]
Ozmen, Bilgin [4 ]
机构
[1] Dokuz Eylul Univ, Dept Internal Med, Div Endocrinol & Metab, Sch Med, TR-35340 Izmir, Turkey
[2] Celal Bayar Univ, Sch Med, Dept Pediat, Div Pediat Cardiol, Manisa, Turkey
[3] Celal Bayar Univ, Sch Med, Dept Radiol, Manisa, Turkey
[4] Celal Bayar Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Manisa, Turkey
来源
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2008年 / 7卷 / 02期
关键词
Overweight; Atherosclerosis; Flow mediated dilatation; HOMA-IR; C-reactive protein;
D O I
10.1007/BF03401507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: Childhood obesity is associated with impaired endothelial function, insulin resistance and inflammation. Being at risk for overweight has been defined as having a body mass index (BMI) between the 85(th) and 94(th) percentile for age and sex. In this study, we looked for features linked to cardiovascular, risk in children who are at risk for overweight. DESIGN: Twenty-one children who were at risk for overweight (study group) and 20 children with a BMI between the 25(th)-74(th) percentiles (controls) were studied. Fasting blood levels of glucose, insulin, total cholesterol, HDL cholesterol, triglycerides, uric acid, fibrinogen and high sensitive C-reactive protein (CRP) were assessed in both groups. LDL-cholesterol, HOMA-IR and QUICKI indices were calculated. Flow-Mediated Vasodilatation (FMD) was determined for the evaluation of endothelial function. RESULTS: Increased HOMA-IR was observed in children who were at risk for overweight. Waist circumference was the main predictor of insulin resistance in these children. Higher levels of CRP were found in the study group compared to controls, while plasma fibrinogen died not differ in the two groups. The children who were at risk for overweight had lower FMD values and slightly elevated lipids compared to controls; however, these differences were not statistically significant. CONCLUSION: Insulin resistance and inflammation indices were higher in children who were at risk for overweight as has been shown for obese children. The data suggest that appropriate treatment strategies for weight control are essential not only for obese children but also for those at risk for overweight.
引用
收藏
页码:156 / 162
页数:7
相关论文
共 27 条
[1]   Obesity evaluation and treatment: Expert committee recommendations [J].
Barlow, SE ;
Dietz, WH .
PEDIATRICS, 1998, 102 (03)
[2]   Body mass index references for Turkish children [J].
Bundak, R ;
Furman, A ;
Gunoz, H ;
Darendeliler, F ;
Bas, F ;
Neyzi, O .
ACTA PAEDIATRICA, 2006, 95 (02) :194-198
[3]   Revisiting the metabolic syndrome [J].
Chew, Gerard T. ;
Gan, Seng Khee ;
Watts, Gerald F. .
MEDICAL JOURNAL OF AUSTRALIA, 2006, 185 (08) :445-449
[4]  
CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
[5]   C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors [J].
Cook, DG ;
Mendall, MA ;
Whincup, PH ;
Carey, IM ;
Ballam, L ;
Morris, JE ;
Miller, GJ ;
Strachan, DP .
ATHEROSCLEROSIS, 2000, 149 (01) :139-150
[6]   Prevention of childhood obesity [J].
Ells, LJ ;
Campbell, K ;
Lidstone, J ;
Kelly, S ;
Lang, R ;
Summerbell, C .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 19 (03) :441-454
[7]   INSULIN AND CARDIOVASCULAR-DISEASE - PARIS PROSPECTIVE-STUDY [J].
FONTBONNE, AM ;
ESCHWEGE, EM .
DIABETES CARE, 1991, 14 (06) :461-469
[8]   C-reactive protein and body mass index in children: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994 [J].
Ford, ES ;
Galuska, DA ;
Gillespie, C ;
Will, JC ;
Giles, WH ;
Dietz, WH .
JOURNAL OF PEDIATRICS, 2001, 138 (04) :486-492
[9]  
Garanty-Bogacka B, 2005, NEUROENDOCRINOL LETT, V26, P473
[10]   OBESITY AS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR-DISEASE - A 26-YEAR FOLLOW-UP OF PARTICIPANTS IN THE FRAMINGHAM HEART-STUDY [J].
HUBERT, HB ;
FEINLEIB, M ;
MCNAMARA, PM ;
CASTELLI, WP .
CIRCULATION, 1983, 67 (05) :968-977