Microwave assisted synthesis of amorphous magnesium phosphate nanospheres

被引:52
作者
Zhou, Huan [1 ]
Luchini, Timothy J. F. [1 ]
Bhaduri, Sarit B. [1 ,2 ]
机构
[1] Univ Toledo, Dept Mech Ind & Mfg Engn, Toledo, OH 43606 USA
[2] Univ Toledo, Dept Surg, Toledo, OH 43606 USA
关键词
CALCIUM-PHOSPHATE; BONE REGENERATION; IN-VITRO; TEMPERATURE; NANOPARTICLES; BIOMATERIALS; FABRICATION;
D O I
10.1007/s10856-012-4743-y
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Magnesium phosphate (MgP) materials have been investigated in recent years for tissue engineering applications, attributed to their biocompatibility and biodegradability. This paper describes a novel microwave assisted approach to produce amorphous magnesium phosphate (AMP) in a nanospherical form from an aqueous solution containing Mg2+ and HPO4 (2-)/PO4 (3-). Some synthesis parameters such as pH, Mg/P ratio, solution composition were studied and the mechanism of AMP precursors was also demonstrated. The as-produced AMP nanospheres were characterized and tested in vitro. The results proved these AMP nanospheres can self-assemble into mature MgP materials and support cell proliferation. It is expected such AMP has potential in biomedical applications.
引用
收藏
页码:2831 / 2837
页数:7
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