CRITERIA FOR AN UPDATED CLASSIFICATION OF HUMAN TRANSCRIPTION FACTOR DNA-BINDING DOMAINS

被引：8
|
作者：
Wingender, Edgar [1 ,2 ]
机构：
[1] Univ Med Ctr Groningen, Dept Bioinformat, D-37077 Gottingen, Germany
[2] geneXplain GmbH, D-38302 Wolfenbuttel, Germany
来源：
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY | 2013年 / 11卷 / 01期
关键词：
Transcription factors; DNA-binding domains; classification; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; COMPLEX REVEALS; GLUCOCORTICOID-RECEPTOR; PROTEIN; BOX; SEQUENCE; RECOGNITION; NOMENCLATURE; ELEMENT;
D O I：
10.1142/S0219720013400076
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.
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页数：21
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