Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes

被引：7

作者：

Worcester, David L. ^{[1
,3
]}

Weinrich, Michael ^{[1
,2
]}

机构：

[1] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA

[2] Eunice Kennedy Shriver Natl Ctr Child Hlth & Huma, NIH, Bethesda, MD 20892 USA

[3] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2015年 / 6卷 / 21期

基金：

美国国家卫生研究院;

关键词：

ANGLE NEUTRON-SCATTERING; GENERAL-ANESTHESIA; PHASE-TRANSITIONS; NMDA RECEPTOR; BILAYERS; MIXTURES; PHOSPHOLIPIDS; CHOLESTEROL; LIPOSOMES; VESICLES;

D O I：

10.1021/acs.jpclett.5b02134

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Neutron diffraction measurements demonstrate that hydrostatic pressure promotes liquid-ordered (L-o) domain formation in lipid membranes prepared as both oriented multilayers and unilamellar vesicles made of a canonical ternary lipid mixture for which demixing transitions have been extensively studied. The results demonstrate an unusually large dependence of the mixing transition on hydrostatic pressure. Additionally, data at 28 degrees C show that the magnitude of increase in Lo caused by 10 MPa pressure is much the same as the decrease in Lo produced by twice minimum alveolar concentrations (MAC) of general anesthetics such as halothane, nitrous oxide, and xenon. Therefore, the results may provide a plausible explanation for the reversal of general anesthesia by hydrostatic pressure.

引用

页码：4417 / 4421

页数：5

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