Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis

被引：22

作者：

Cheng, Weijia ^{[1
]}

Li, Xiao ^{[1
]}

Liu, Dongling ^{[1
]}

Cui, Chaochu ^{[1
]}

Wang, Xianwei ^{[1
]}

机构：

[1] Xinxiang Med Univ, Henan Key Lab Med Tissue Regenerat, Xinxiang 453003, Henan, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS | 2021年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

endothelial-to-mesenchymal transition; cardiac fibrosis; cardiovascular diseases; TGF-beta signaling; oxidative stress; microRNAs; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; E-CADHERIN; SNAIL; CELLS; PATHWAY; CONTRIBUTES; REPRESSION; EXPRESSION; INDUCTION;

D O I：

10.1177/1074248420952233

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions.

引用

页码：3 / 11

页数：9

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