Effectiveness of First-line Antiretroviral Therapy and Acquired Drug Resistance Among HIV-1-infected Children in India

被引：9

作者：

Shet, Anita ^{[1
,2
]}

Neogi, Ujjwal ^{[3
,4
]}

Sahoo, Pravat Nalini ^{[3
]}

De Costa, Ayesha ^{[2
]}

机构：

[1] St Johns Med Coll & Hosp, Dept Paediat, Bangalore, Karnataka, India

[2] Karolinska Inst, Div Global Hlth, S-10401 Stockholm, Sweden

[3] St Johns Med Coll & Hosp, Div Clin Virol, Dept Microbiol, Bangalore, Karnataka, India

[4] Karolinska Inst, Dept Med, Div Infect Dis, Huddinge, Sweden

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 05期

关键词：

pediatric antiretroviral treatment; effectiveness; virological failure; drug resistance; HIV-INFECTED CHILDREN; VIRAL LOAD; FAILURE;

D O I：

10.1097/INF.0b013e31827fb2d1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Analysis of treatment response among HIV-infected children in India on first-line antiretroviral treatment for >2 years revealed that 85% were virologically suppressed. Of those with virologic failure, only 17% manifested immunologic failure, whereas majority had resistance-associated mutations. The presence of resistance highlights the need for virologic monitoring of children receiving antiretroviral treatment to optimize treatment success and preserve future treatment options.

引用

页码：E227 / E229

页数：3

共 13 条

[1] First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial [J].

Babiker, Abdel ;

Castro , Hannah ;

Compagnucci, Alexandra ;

Fiscus, Susan ;

Giaquinto, Carlo ;

Gibb, Diana M. ;

Harper, Lynda ;

Harrison, Linda ;

Hughes, Michael ;

McKinney, Ross ;

Melvin, Ann ;

Mofenson, Lynne ;

Saidi, Yacine ;

Smith, M. Elizabeth ;

Tudor-Williams, Gareth ;

Walker, A. Sarah .

LANCET INFECTIOUS DISEASES, 2011, 11 (04) :273-283

[2] Immunologic and virologic failure after first-line NNRTI-based antiretroviral therapy in Thai HIV-infected children [J].

Bunupuradah, Torsak ;

Puthanakit, Thanyawee ;

Kosalaraksa, Pope ;

Kerr, Stephen ;

Boonrak, Pitch ;

Prasitsuebsai, Wasana ;

Lumbiganon, Pagakrong ;

Mengthaisong, Tawan ;

Phasomsap, Chayapa ;

Pancharoen, Chitsanu ;

Ruxrungtham, Kiat ;

Ananworanich, Jintanat .

AIDS RESEARCH AND THERAPY, 2011, 8

[3] Drug Resistance in Human Immunodeficiency Virus Type-1 Infected Zambian Children Using Adult Fixed Dose Combination Stavudine, Lamivudine, and Nevirapine [J].

Gupta, Ravindra K. ;

Ford, Deborah ;

Mulenga, Veronica ;

Walker, A. Sarah ;

Kabamba, Desire ;

Kalumbi, Moxmalama ;

Grant, Paul R. ;

Ferrier, Alexander ;

Pillay, Deenan ;

Gibb, Diana M. ;

Chintu, Chifumbe .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2010, 29 (08) :E57-E62

[4] Effectiveness of highly active antiretroviral therapy in HIV-positive children: Evaluation at 12 months in a routine program in Cambodia [J].

Janssens, Bart ;

Raleigh, Brian ;

Soeung, Seithaboth ;

Akao, Kazumi ;

Te, Vantha ;

Gupta, Jitendra ;

Vun, Mean Chhy ;

Ford, Nathan ;

Nouhin, Janin ;

Nerrienet, Eric .

PEDIATRICS, 2007, 120 (05) :E1134-E1140

[5] Safety, Tolerability and Effectiveness of Generic HAART in HIV-Infected Children in South India [J].

Kumarasamy, N. ;

Venkatesh, Kartik K. ;

Devaleenol, Bella ;

Poongulali, S. ;

Mothi, S. N. ;

Solomon, Suniti .

JOURNAL OF TROPICAL PEDIATRICS, 2009, 55 (03) :155-159

[6]

National AIDS Control Organization Ministry of Health and Family Welfare Government of India, NAT AIDS CONTR ORG A

[7]

Neogi U, 2012, INDIAN J MED RES, V136, P956

[8] Naturally Occurring Polymorphisms and Primary Drug Resistance Profile Among Antiretroviral-Naive Individuals in Bangalore, India [J].

Neogi, Ujjwal ;

Prarthana, B. S. ;

Gupta, Soham ;

D'souza, George ;

De Costa, Ayesha ;

Kuttiatt, Vijesh Sreedhar ;

Arumugam, Karthika ;

Shet, Anita .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2010, 26 (10) :1097-1101

[9] In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy [J].

O'Brien, Daniel P. ;

Sauvageot, Delphine ;

Zachariah, Rony ;

Humblet, Pierre .

AIDS, 2006, 20 (15) :1955-1960

[10] Viral Load Predicts New World Health Organization Stage 3 and 4 Events in HIV-Infected Children Receiving Highly Active Antiretroviral Therapy, Independent of CD4 T Lymphocyte Value [J].

Oliveira, Ricardo ;

Krauss, Margot ;

Essama-Bibi, Suzanne ;

Hofer, Cristina ;

Harris, D. Robert ;

Tiraboschi, Adriana ;

de Souza, Ricardo ;

Marques, Heloisa ;

Succi, Regina ;

Abreu, Thalita ;

Della Negra, Marinella ;

Hazra, Rohan ;

Mofenson, Lynne M. ;

Siberry, George K. .

CLINICAL INFECTIOUS DISEASES, 2010, 51 (11) :1325-1333

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