Gene expression profile of aquaporin 1 and associated interactors in malignant pleural mesothelioma

被引：15
作者：
Jagirdar, Rajesh [1 ]
Solenov, Evgeniy I. [2 ,3 ]
Hatzoglou, Chrissi [4 ]
Molyvdas, Paschalis-Adam [4 ]
Gourgoulianis, Konstantinos I. [5 ]
Zarogiannis, Sotirios G. [4 ,5 ]
机构：
[1] GeneClick Org, Hyderabad, Andhra Pradesh, India
[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
[3] Novosibirsk State Univ, Novosibirsk 630090, Russia
[4] Univ Thessaly, Sch Med, Dept Physiol, BIOPOLIS, Larisa 41110, Greece
[5] Univ Thessaly, Sch Med, Dept Resp Med, BIOPOLIS, Larisa 41110, Greece
来源：
GENE | 2013年 / 517卷 / 01期
关键词：
Aquaporin-1; Gene expression profile; Malignant pleural mesothelioma; Pleural fluid transport; Protein-protein interactions; P16/CDKN2A DELETION; PROGNOSTIC-FACTORS; WATER CHANNELS; CUTIS LAXA; PROTEIN; FIBULIN-4; TRIP6; OVEREXPRESSION; ASBESTOS; DATABASE;
D O I：
10.1016/j.gene.2012.12.075
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Overexpression of AQP1 has recently been shown to be an independent prognostic factor in pleural mesothelioma favoring survival. This paper presents a data mining and bioinformatics approach towards the evaluation of the gene expression profile of AQP1 in malignant pleural mesothelioma and of AQP1 associated markers in the context of mesothelioma disease phenotype, CDKN2A gene deletion, sex and asbestos exposure. The data generated were thus again subjected to differential expression profile analysis. Here we report that AQP1 is overexpressed in epithelioid mesothelioma and identify TRIP6 and EFEMP2 as candidate genes for further investigation in mesothelioma. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：99 / 105
页数：7
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