A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma

被引：25
作者：
Vangsted, Annette J. [1 ]
Nielsen, Kaspar R. [2 ]
Klausen, Tobias W. [3 ]
Haukaas, Einar [4 ]
Tjonneland, Anne [5 ]
Vogel, Ulla [6 ]
机构：
[1] Univ Copenhagen, Roskilde Hosp, Dept Haematol, DK-4000 Roskilde, Denmark
[2] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Immunol, Aalborg, Denmark
[3] Hosp Copenhagen Herlev, Dept Haematol, Herlev, Denmark
[4] Univ Hosp Stavanger, Dept Hematol, Stavanger, Norway
[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark
[6] Natl Res Ctr Working Environm, Copenhagen, Denmark
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2012年 / 158卷 / 04期
关键词：
multiple myeloma; IL1B; NFKB1; polymorphism;
D O I：
10.1111/j.1365-2141.2012.09141.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cytokine interleukin-1 beta (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0.58 (95% confidence interval (CI) = 0.410.84) and RR 0.59 (95%CI 0.400.85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.
引用
收藏
页码：515 / 518
页数：4
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