Calixarene-based chiral primary amine thiourea promoted highly enantioselective asymmetric Michael reactions of α,α-disubstituted aldehydes with maleimides

被引：31

作者：

Durmaz, Mustafa ^{[1
]}

Sirit, Abdulkadir ^{[1
]}

机构：

[1] Necmettin Erbakan Univ, Dept Chem, TR-42099 Meram, Konya, Turkey

来源：

TETRAHEDRON-ASYMMETRY | 2013年 / 24卷 / 23期

关键词：

CONJUGATE ADDITION; BIFUNCTIONAL ORGANOCATALYSTS; MOLECULAR RECOGNITION; OPTICAL RESOLUTION; SCAFFOLD; CONE; RIM;

D O I：

10.1016/j.tetasy.2013.09.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Calix[4]arene based chiral bifunctional thiourea-primary amines have been shown to act as effective catalysts for the Michael addition of aldehydes to maleimides for the first time. The corresponding adducts were generally obtained preferentially in (R)- or (S)-forms with high yields (up to 99%) and with high to excellent enantioselectivities (up to 98% ee). (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1443 / 1448

页数：6

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