Novel synthesis of aminoacetonitriles via the selective demethylation of quaternary ammonium salts

被引：6

作者：

Buev, Evgeny M. ^{[1
]}

Smorodina, Anastasia A. ^{[1
]}

Stepanov, Maxim A. ^{[1
]}

Moshkin, Vladimir S. ^{[1
]}

Sosnovskikh, Vyacheslav Y. ^{[1
]}

机构：

[1] Ural Fed Univ, Inst Nat Sci & Math, Ekaterinburg 620000, Russia

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 17期

基金：

俄罗斯科学基金会;

关键词：

Quaternary ammonium salts; alpha-Aminonitriles; Saturated N-heterocycles; Nonstabilized azomethine ylides; NONSTABILIZED AZOMETHINE YLIDES; TERTIARY-AMINES; ALKYLAMINOMETHYLATION; 5-ARYLOXAZOLIDINES; FUNCTIONALIZATION; REARRANGEMENT; PYRROLIDINES; CHERYLLINE; ALKYLATION; ALKALOIDS;

D O I：

10.1016/j.tetlet.2018.03.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Methyl cyclic amines readily formed quaternary ammonium salts upon treatment with iodoacetonitrile in high yields (70-96%). The latter were selectively demethylated by heating in dimethylformamide to give aminoacetonitriles in moderate to good overall yields (36-69%). (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1638 / 1641

页数：4

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