Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives

被引：78
作者：
Abbas, Samir Y. [1 ]
Farag, Awatef A. [2 ,3 ]
Ammar, Yousry A. [3 ,4 ]
Atrees, Abeer A. [2 ]
Mohamed, Aly F. [5 ]
El-Henawy, Ahmed A. [3 ]
机构：
[1] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt
[2] Taif Univ, Dept Chem, Fac Educ, At Taif, Saudi Arabia
[3] Al Azhar Univ Girls, Fac Sci, Dept Chem, Cairo, Egypt
[4] King Khaled Univ, Fac Sci, Dept Chem, Abha, Saudi Arabia
[5] VACSERA, Appl Res Sect, Cairo, Egypt
来源：
MONATSHEFTE FUR CHEMIE | 2013年 / 144卷 / 11期
关键词：
Schiff bases; Carbonyl compounds; Thiosemicarbazones; Thiazoles; BETA-THIOSEMICARBAZONE; INVITRO TRANSLATION; VIRUS; INHIBITION; CHEMISTRY; DESIGN; MOIETY;
D O I：
10.1007/s00706-013-1034-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New series of Schiff's bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity.
引用
收藏
页码：1725 / 1733
页数：9
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