The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials

被引:21
作者
Leaper, David [1 ]
Muenter, Christian
Meaume, Sylvie [2 ]
Scalise, Alessandro [3 ]
Blanes Mompo, Nacho [4 ]
Jakobsen, Birte Petersen [5 ]
Gottrup, Finn [6 ]
机构
[1] Cardiff Univ, Wound Healing Res Unit, Cardiff CF10 3AX, S Glam, Wales
[2] Hop Rothschild, F-75571 Paris, France
[3] Ancona Politech Univ, Fac Med, Ancona, Italy
[4] Hosp Manises, Valencia, Spain
[5] Coloplast AS, Humlebaek, Denmark
[6] Bispebjerg Hosp, Copenhagen Wound Healing Ctr, Copenhagen, Denmark
来源
PLOS ONE | 2013年 / 8卷 / 07期
关键词
SILVER-RELEASING DRESSINGS; WOUND CARE; MANAGEMENT; PREVALENCE; VULCAN;
D O I
10.1371/journal.pone.0067083
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs). Aim: To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing. Patients and Methods: 685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis. Results: Biatain Ag showed a significant treatment effect (p < 0.0001), responder rate (p < 0.001), and healing rate (p = 0.002). Conclusion: The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.
引用
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页数:7
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