Extraction of Nobiletin and Tangeretin From Peels of Shekwasha and Ponkan Using [C2mim][(MeO)(H)PO2] and Centrifugation

被引：13

作者：

Mizuno, Hitomi ^{[1
]}

Yoshikawa, Hibiki ^{[1
]}

Usuki, Toyonobu ^{[1
]}

机构：

[1] Sophia Univ, Fac Sci & Technol, Dept Mat & Life Sci, Tokyo, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 05期

关键词：

extraction; nobiletin; tangeretin; Ionic liquid;

D O I：

10.1177/1934578X19845816

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The polymethoxyflavonoids nobiletin and tangeretin are isolated from peels of shekwasha (Citrus depressa Hayata) and ponkan (Citrus reticulata Blanco). These natural products possess biological activities, including anticancer and anti-inflammation properties. This report describes an efficient method for the extraction and isolation of nobiletin and tangeretin from citrus peels using 1-ethyl-3-methylimidazolium methylphosphonate ([C(2)mim][(MeO)(H)PO2]) and centrifugation/decantation. The results showed that the extraction yield of nobiletin and tangeretin using [C(2)mim][(MeO)(H)PO2]/organic solvent (1:1 w/w) was 1.4 to 1.6 times higher than that using organic solvent. This extraction method is expected to be applicable for obtaining other organic compounds from natural sources.

引用

页数：6

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