Extraction of Nobiletin and Tangeretin From Peels of Shekwasha and Ponkan Using [C2mim][(MeO)(H)PO2] and Centrifugation

被引：13

作者：

Mizuno, Hitomi ^{[1
]}

Yoshikawa, Hibiki ^{[1
]}

Usuki, Toyonobu ^{[1
]}

机构：

[1] Sophia Univ, Fac Sci & Technol, Dept Mat & Life Sci, Tokyo, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 05期

关键词：

extraction; nobiletin; tangeretin; Ionic liquid;

D O I：

10.1177/1934578X19845816

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The polymethoxyflavonoids nobiletin and tangeretin are isolated from peels of shekwasha (Citrus depressa Hayata) and ponkan (Citrus reticulata Blanco). These natural products possess biological activities, including anticancer and anti-inflammation properties. This report describes an efficient method for the extraction and isolation of nobiletin and tangeretin from citrus peels using 1-ethyl-3-methylimidazolium methylphosphonate ([C(2)mim][(MeO)(H)PO2]) and centrifugation/decantation. The results showed that the extraction yield of nobiletin and tangeretin using [C(2)mim][(MeO)(H)PO2]/organic solvent (1:1 w/w) was 1.4 to 1.6 times higher than that using organic solvent. This extraction method is expected to be applicable for obtaining other organic compounds from natural sources.

引用

页数：6

共 18 条

[1] Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways [J].

Dong, Yang ;

Cao, Aili ;

Shi, Jianrong ;

Yin, Peihao ;

Wang, Li ;

Ji, Guang ;

Xie, Jianqun ;

Wu, Dazheng .

ONCOLOGY REPORTS, 2014, 31 (04) :1788-1794

[2] The methoxyflavones in Citrus reticulata Blanco cv. ponkan and their antiproliferative activity against cancer cells [J].

Du, Qizhen ;

Chen, Hui .

FOOD CHEMISTRY, 2010, 119 (02) :567-572

[3] Ionic liquid (molten salt) phase organometallic catalysis [J].

Dupont, J ;

de Souza, RF ;

Suarez, PAZ .

CHEMICAL REVIEWS, 2002, 102 (10) :3667-3691

[4] Cellulose dissolution with polar ionic liquids under mild conditions: required factors for anions [J].

Fukaya, Yukinobu ;

Hayashi, Kensaku ;

Wada, Masahisa ;

Ohno, Hiroyuki .

GREEN CHEMISTRY, 2008, 10 (01) :44-46

[5] Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium) [J].

Ho, Su-Chen ;

Kuo, Chun-Ting .

FOOD AND CHEMICAL TOXICOLOGY, 2014, 71 :176-182

[6] Multi-lineages of Shiikuwasha (Citrus depressa Hayata) evaluated by using whole chloroplast genome sequences and its bio-diversity in Okinawa, Japan [J].

Ishikawa, Ryuji ;

Badenoch, Nathan ;

Miyagi, Kunimasa ;

Medoruma, Kaname ;

Osada, Toshiki ;

Onishi, Masayuki .

BREEDING SCIENCE, 2016, 66 (04) :490-498

[7] Soluble and insoluble phenolic compounds and antioxidant activity of immature calamondin affected by solvents and heat treatment [J].

Lou, Shyi-Neng ;

Lin, Yu-Shan ;

Hsu, Ya-Siou ;

Chiu, E-Ming ;

Ho, Chi-Tang .

FOOD CHEMISTRY, 2014, 161 :246-253

[8] Ionic Liquid-Assisted Extraction and Isolation of Cynaropicrin and Cnicin from Artichoke and Blessed thistle [J].

Mizuno, Hitomi ;

Usuki, Toyonobu .

CHEMISTRYSELECT, 2018, 3 (06) :1781-1786

[9]

MIZUNO M, 1991, CHEM PHARM BULL, V39, P945, DOI 10.1248/cpb.39.945

[10] Improved Extraction Yield of Citral from Lemon Myrtle Using a Cellulose-Dissolving Ionic Liquid [J].

Munakata, Koki ;

Yoshizawa-Fujita, Masahiro ;

Rikukawa, Masahiro ;

Usuki, Toyonobu .

AUSTRALIAN JOURNAL OF CHEMISTRY, 2017, 70 (06) :699-704

← 1 2 →