Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy

被引：0
作者：
Carvalho, A. Vitorino [1 ,4 ]
Eozenou, C. [1 ,5 ]
Richard, C. [1 ]
Forde, N. [2 ]
Healey, G. D. [3 ]
Giraud-Delville, C. [1 ]
Mansouri-Attia, N. [1 ,6 ]
Lonergan, P. [2 ]
Sheldon, I. M. [3 ]
Sandra, O. [1 ]
机构：
[1] Univ Paris Saclay, UMR BDR, INRA, ENVA, F-78350 Jouy En Josas, France
[2] Univ Coll Dublin, Sch Agr & Food Sci, Dublin, Ireland
[3] Swansea Univ, Sch Med, Inst Life Sci, Singleton Pk, Swansea SA2 8PP, W Glam, Wales
[4] Univ Tours, INRA, BOA, F-37380 Nouzilly, France
[5] Inst Pasteur, Human Dev Genet, F-75724 Paris, France
[6] Braverman IVF & Reprod Immunol, 888 Pk Ave, New York, NY 10075 USA
来源：
REPRODUCTION FERTILITY AND DEVELOPMENT | 2019年 / 31卷 / 06期
基金：
爱尔兰科学基金会; 英国生物技术与生命科学研究理事会;
关键词：
cattle; implantation; GENE-EXPRESSION; CONCEPTUS SIGNALS; TH1/TH2; PARADIGM; INTERFERON-TAU; IMMUNE CELLS; SOCS GENES; PROGESTERONE; TRANSCRIPTOME; IMPLANTATION; RECOGNITION;
D O I：
10.1071/RD18411
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In mammals, tight regulation of maternal endometrial function is critical for pregnancy success. In bovine species, endometrial expression of members of the scavenger receptor class A (SR-A) has been listed in high-throughput analyses, but very little is known about the involvement of these immune factors during implantation in mammals. To provide first insights into the contribution of SR-A to endometrial physiology, we analysed the expression and regulation of all members of SR-A (SR-A1, SR-A3-SR-A6) during the oestrous cycle and early pregnancy in cattle. Levels of SR-A1 were increased on Day 20 of pregnancy, whereas SR-A3 levels were increased on Day 13 of the oestrous cycle and of the pregnancy. Although SR-A4 levels were reduced on Day 20 of the oestrous cycle, they remained high in pregnant animals. SR-A5 levels increased by Day 13 of the oestrous cycle and decreased on Day 20, but remained high in pregnant animals. Interferon- does not affect SR-A gene expression, whereas progesterone regulates the expression of the SR-A3 and SR-A5 transcripts. Endometrial SR-A3 appeared significantly higher in cows carrying invitro-produced embryos than in AI cows. Our data suggest that members of the SR-A family are involved in endometrial remodelling and regulation of endometrial gland physiology, both processes being critical for implantation in mammals.
引用
收藏
页码：1078 / 1090
页数：13
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