Dendritic cells and vaccine design for sexually-transmitted diseases

被引：9

作者：

Duluc, Dorothee ^{[1
]}

Gannevat, Julien ^{[1
]}

Joo, HyeMee ^{[1
]}

Ni, Ling ^{[1
]}

Upchurch, Katherine ^{[2
]}

Boreham, Muriel ^{[3
]}

Carley, Michael ^{[3
]}

Stecher, Jack ^{[3
]}

Zurawski, Gerard ^{[1
]}

Oh, SangKon ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

[2] Baylor Univ, Inst Biomed Studies, Waco, TX 76706 USA

[3] Baylor Univ, Med Ctr, Dept Obstet & Gynecol, Dallas, TX 75246 USA

来源：

MICROBIAL PATHOGENESIS | 2013年 / 58卷

关键词：

Dendritic cells; Vaccines; Genital; Mucosa; Sexually-transmitted diseases; HERPES-SIMPLEX-VIRUS; FEMALE GENITAL-TRACT; CD4(+) T-CELLS; HIV GAG PROTEIN; CHRONIC MUCOCUTANEOUS CANDIDIASIS; HUMAN-PAPILLOMAVIRUS TYPE-16; PERIPHERAL LYMPHOID ORGANS; HUMAN LANGERHANS CELLS; NATURAL-KILLER-CELLS; COMPLEX CLASS-I;

D O I：

10.1016/j.micpath.2012.11.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are major antigen presenting cells (APCs) that can initiate and control host immune responses toward either immunity or tolerance. These features of DCs, as immune orchestrators, are well characterized by their tissue localizations as well as by their subset-dependent functional specialties and plasticity. Thus, the level of protective immunity to invading microbial pathogens can be dependent on the subsets of DCs taking up microbial antigens and their functional plasticity in response to microbial products, host cellular components and the cytokine milieu in the microenvironment. Vaccines are the most efficient and cost-effective preventive medicine against infectious diseases. However, major challenges still remain for the diseases caused by sexually-transmitted pathogens, including HIV, HPV, HSV and Chlamydia. We surmise that the establishment of protective immunity in the female genital mucosa, the major entry and transfer site of these pathogens, will bring significant benefit for the protection against sexually-transmitted diseases. Recent progresses made in DC biology suggest that vaccines designed to target proper DC subsets may permit us to establish protective immunity in the female genital mucosa against sexually-transmitted pathogens. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：35 / 44

页数：10

共 189 条

[1] Toll-like receptors: critical proteins linking innate and acquired immunity [J].