A BODIPY fluorescent probe with selective response for hypochlorous acid and its application in cell imaging

被引：50

作者：

Gai, Lizhi ^{[1
]}

Mack, John ^{[2
]}

Liu, Hui ^{[1
]}

Xu, Zheng ^{[1
]}

Lu, Hua ^{[1
]}

Li, Zhifang ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 310012, Zhejiang, Peoples R China

[2] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2013年 / 182卷

关键词：

Hypochlorous acid; BODIPY; TD-DFT; Fluorescent probe; Cell image; INTRAMOLECULAR CHARGE-TRANSFER; TURN-ON; ELECTRON-TRANSFER; SYNOVIAL-FLUID; DYES; ATHEROSCLEROSIS; OXIDATION; STATE; RED;

D O I：

10.1016/j.snb.2013.02.106

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A boron-dipyrromethene (BODIPY) derivative with a hydroxymethyl group at the mesa-position, 1, was synthesized, which exhibits a highly specific and rapid 'turn-off' response for HOCl during confocal fluorescence microscopy experiments under physiological conditions and in live cells. The formation of an electron-withdrawing formyl substituent upon oxidation results in highly efficient nonradiative decay of the S-1 state and hence in a drastic decrease in fluorescence emission intensity. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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