Transcription factor-induced enhancer modulations during cell fate conversions

被引：10

作者：

van Oevelen, C. ^{[1
]}

Kallin, E. M.

Graf, T.

机构：

[1] Ctr Genom Regulat, Gene Regulat Stem Cells & Canc Program, Barcelona, Spain

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2013年 / 23卷 / 05期

关键词：

ELEGANS GERM-CELLS; GENE-EXPRESSION; BINDING PROTEIN; DEFINED FACTORS; B-CELLS; CHROMATIN; TRANSDIFFERENTIATION; FIBROBLASTS; MACROPHAGE; IDENTITY;

D O I：

10.1016/j.gde.2013.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The activity of transcription factors (TFs) has empowered the reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) and alternative lineages. Elucidation of the molecular mechanisms underpinning these processes has expanded our understanding of how novel gene expression programs become activated while old ones are silenced [1-3]. How TFs modify chromatin and activate requisite enzymes during these processes has recently been discussed in several excellent reviews [4-6]. Here we discuss the questions of how ectopically expressed TFs access chromatin to modulate enhancers and establish a novel transcriptome during cell reprogramming, lineage conversions and differentiation.

引用

页码：562 / 567

页数：6

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