Macro- and microvascular disease in systemic sclerosis

被引：28
作者：
Kavian, Niloufar [1 ,2 ]
Batteux, Frederic [1 ,2 ]
机构：
[1] Inst Cochin Genet Mol, INSERM, Sorbonne Paris Cite, Fac Med Paris Descartes,U1016, F-75014 Paris, France
[2] Hop Cochin, AP HP, Grp Hosp Paris Ctr, Lab Immunol Biol, F-75679 Paris 14, France
来源：
VASCULAR PHARMACOLOGY | 2015年 / 71卷
关键词：
Vasculopathy; Systemic sclerosis; Endothelial cells; Pericytes; Angiogenesis; Vasculogenesis; Reactive oxygen species; Endo-mesenchymal transistion; PULMONARY ARTERIAL-HYPERTENSION; VONWILLEBRAND-FACTOR ANTIGEN; ENDOTHELIAL GROWTH-FACTOR; RAYNAUDS-PHENOMENON; PHOSPHODIESTERASE-5; INHIBITORS; CAPILLAROSCOPIC PATTERNS; VASCULAR INVOLVEMENT; INCREASED PREVALENCE; SCLERODERMA; ANGIOGENESIS;
D O I：
10.1016/j.vph.2015.05.015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vasculopathy is common in patients with connective tissue disease and can be directly implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune multiorgan connective tissue disorder characterized by fibrosis of the skin and visceral organs and vascular disease. Micro- and macro-vessels are a direct target of the disease. In this review, we present the various clinical manifestations of the vasculopathy that can be present in SSc patients, and then discuss the various aspects of the pathophysiology of the vascular disorders. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：16 / 23
页数：8
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