Magnetization transfer MRI in pancreatic cancer xenograft models

被引：32
作者：
Li, Weiguo [1 ]
Zhang, Zhuoli [1 ,2 ]
Nicolai, Jodi [1 ]
Yang, Guang-Yu [2 ,3 ]
Omary, Reed A. [1 ,2 ,4 ]
Larson, Andrew C. [1 ,2 ,4 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA
[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
[4] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
来源：
MAGNETIC RESONANCE IN MEDICINE | 2012年 / 68卷 / 04期
关键词：
magnetization transfer; fibrosis; pancreatic cancer; mouse xenograft model; LIVER FIBROSIS; CARTILAGE; EVALUATE; THERAPY; MAP;
D O I：
10.1002/mrm.24127
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Magnetization transfer magnetic resonance imaging measurements were performed in three pancreatic ductal adenocarcinoma mouse xenograft models. For each of 28 pancreatic ductal adenocarcinoma xenografts, MT ratios (MTRs) were calculated and compared to histologic fibrosis levels from reference standard trichrome staining. MTR was found to be significantly higher in tumors grown using BxPC-3 cell line (39.4 +/- 5.1, mean +/- SD) compared to the MTR for the tumors grown from Panc-1 (32.4 +/- 2.8) and Capan-1 (27.3 +/- 2.9) cell lines (P < 0.05 for each comparison). Histologic measurements showed a similar trend with BxPC-3 tumors demonstrating significantly higher fibrosis levels (percentage of fibrotic tissue area, 6.48 +/- 2.59) when compared to Panc-1 (3.54 +/- 2.18) and Capan-1 (2.07 +/- 1.60) tumors. MTR measurements were well correlated to quantitative fibrosis levels (r = 0.69, P = 0.01). Results indicated that MTR measurements offer the potential to serve as a valuable in vivo biomarker of desmoplasia in pancreatic ductal adenocarcinoma. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.
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收藏
页码：1291 / 1297
页数：7
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