Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats

被引：16
作者：
Al Moutaery, Meshal [2 ]
Al Rayes, Hannan [3 ]
Al Swailam, Ramaiz [3 ]
Elfaki, Ibrahim [1 ]
Khan, Haseeb Ahmad [4 ]
Arshaduddin, Mohammad [1 ]
Tariq, Mohammad [1 ]
机构：
[1] Armed Forces Hosp, Res Ctr, Riyadh 11159, Saudi Arabia
[2] Armed Forces Hosp, Prince Sultan Cardiac Ctr, Riyadh 11159, Saudi Arabia
[3] Armed Forces Hosp, Dept Med, Riyadh 11159, Saudi Arabia
[4] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia
来源：
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2012年 / 64卷 / 03期
关键词：
Cysteine precursor; Anitoxidant; Gastric secretion; Gastric ulcer; Sulfhydryls; Myeloperoxidase; Glutathione; N-ACETYLCYSTEINE; MUCOSAL DEFENSE; ACID; GLUTATHIONE; MUCUS; INFLAMMATION; REVERSES; ALPHA; INTERLEUKIN-2; CYTOTOXICITY;
D O I：
10.1016/j.etp.2010.08.012
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Earlier studies have suggested an important role of glutathione (GSH) in cytoprotection against free radicals induced oxidative damage. This study reports gastroprotective effects of a cysteine precursor, L-2-oxothiazolidine-4-carboxylate (OTC), in experimental models of gastric secretion and ulceration. Acid secretion studies (volume and acidity) were undertaken in pylorus-ligated rats whereas the gastric lesions were induced by ethanol. Different groups of animals were treated with OTC (0, 100, 200 and 400 mg/kg). The levels of gastric wall mucus, nonprotein sulfhydryls (NP-SH) and myeloperoxidase (MPO) were measured in the glandular stomach of rats following ethanol-induced gastric lesions. Both medium and high doses of OTC significantly reduced the volume and acidity of gastric secretion in pylorus-ligated rats. Pretreatment with OTC significantly and dose-dependently attenuated the formation of ethanol-induced gastric lesion. OTC significantly protected the gastric mucosa against ethanol-induced depletion of gastric wall mucus, NP-SH and MPO. The gastroprotective effects of OTC may be attributed to its ability to inhibit neutrophils activity and replenish GSH demand. (C) 2010 Elsevier GmbH. All rights reserved.
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收藏
页码：233 / 237
页数：5
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