Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity

被引：43

作者：

Giessen, Tobias W. ^{[1
]}

Marahiel, Mohamed A. ^{[1
]}

机构：

[1] Univ Marburg, Dept Chem Biochem, D-35032 Marburg, Germany

来源：

FEBS LETTERS | 2012年 / 586卷 / 15期

关键词：

Combinatorial biosynthesis; Synthetic biology; Protein engineering; Metabolic engineering; Directed evolution; Ribosome-independent peptides; NATURAL-PRODUCT GLYCOSYLTRANSFERASE; COMMUNICATION-MEDIATING DOMAINS; DIRECTED EVOLUTION; NUCLEOSIDE ANTIBIOTICS; ADENYLATION DOMAINS; PACIDAMYCIN GROUP; COMBINATORIAL BIOSYNTHESIS; BIOCOMBINATORIAL SYNTHESIS; NONRIBOSOMAL BIOSYNTHESIS; STREPTOMYCES-ROSEOSPORUS;

D O I：

10.1016/j.febslet.2012.01.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide natural products continue to play an important role in modern medicine as last-resort treatments of many life-threatening diseases, as they display many interesting biological activities ranging from antibiotic to antineoplastic. A large fraction of these microbial natural products is assembled by ribosome-independent mechanisms. Progress in sequencing technology and the mechanistic understanding of secondary metabolite pathways has led to the discovery of many formerly cryptic natural products and a molecular understanding of their assembly. Those advances enable us to apply protein and metabolic engineering approaches towards the manipulation of biosynthetic pathways. In this review we discuss the application potential of both templated and non-templated pathways as well as chemoenzymatic strategies for the structural diversification and tailoring of peptide natural products. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2065 / 2075

页数：11

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