Advances in TERS (tip-enhanced Raman scattering) for biochemical applications

被引：67
作者：
Treffer, Regina [1 ]
Boehme, Rene [2 ]
Deckert-Gaudig, Tanja [1 ]
Lau, Katherine [1 ]
Tiede, Stephan [3 ]
Lin, Xiumei [1 ]
Deckert, Volker [1 ,2 ]
机构：
[1] IPHT Inst Photon Technol, D-07745 Jena, Germany
[2] Univ Jena, Inst Phys Chem, D-07743 Jena, Germany
[3] Univ Klinikum Schleswig Holstein, D-23538 Lubeck, Germany
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷
关键词：
atomic force microscopy; biochemical analysis; cytochrome c; epithelial progenitor cell (ePC); nanoscale domain; tip-enhanced Raman scattering (TERS); WALL CARBON NANOTUBES; DIFFRACTION-LIMIT; CYTOCHROME-C; SURFACE; SPECTROSCOPY; SPECTRA; SERS; NUCLEOBASES; CELLS; TOP;
D O I：
10.1042/BST20120033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TERS (tip-enhanced Raman scattering) provides exceptional spatial resolution without any need for labelling and has become a versatile tool for biochemical analysis. Two examples will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c, leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule analysis is discussed, again based on TERS experiments on DNA and RNA, further highlighting the resolution capabilities of this method.
引用
收藏
页码：609 / 614
页数：6
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