Treatment of Multidrug-Resistant Gram-Negative Infections in Children

被引：117

作者：

Hsu, Alice J. ^{[1
]}

Tamma, Pranita D. ^{[2
]}

机构：

[1] Johns Hopkins Univ Hosp, Div Pediat Pharm, Dept Pharm, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Infect Dis, Baltimore, MD 21287 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 10期

关键词：

extended-spectrum beta-lactamases; carbapenemases; AmpC beta-lactamases; Acinetobacter baumannii; Pseudomonas aeruginosa; VENTILATOR-ASSOCIATED PNEUMONIA; CRITICALLY-ILL PATIENTS; AMPC BETA-LACTAMASE; BROAD-SPECTRUM CEPHALOSPORINS; KLEBSIELLA-PNEUMONIAE; URINARY-TRACT; ACINETOBACTER-BAUMANNII; INTRAVENOUS COLISTIN; ESCHERICHIA-COLI; PIPERACILLIN-TAZOBACTAM;

D O I：

10.1093/cid/ciu069

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibiotic resistance in conjunction with the erosion of the drug development pipeline may lead us into a bleak future, a "post-antibiotic era."Because of a shortage of studies addressing treatment options for multidrug-resistant Gram-negative (MDRGN) infections in children, data must be extrapolated from the adult literature. However, even adult studies are limited by significant methodological flaws. We are in urgent need of pediatric specific pharmacokinetic/pharmacodynamic data for agents with activity against MDRGN infections as well as improved clinical outcomes studies. For the time being, we must rely on in vitro studies, observational data, and clinical experience to guide our therapeutic decisions. In this review, we discuss treatment considerations for infections caused by extended-spectrum beta-lactamase-producing organisms, AmpC beta-lactamase-producing organisms, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii in the pediatric population.

引用

页码：1439 / 1448

页数：10

共 100 条

[1] Efficacy and Safety of Cefepime in Pediatric Patients: A Systematic Review and Meta-Analysis [J].

Adderson, Elisabeth E. ;

Flynn, Patricia M. ;

Hoffman, James M. .

JOURNAL OF PEDIATRICS, 2010, 157 (03) :490-U185

[2] Higher Incidence of Acute Kidney Injury With Intravenous Colistimethate Sodium Compared With Polymyxin B in Critically Ill Patients at a Tertiary Care Medical Center [J].

Akajagbor, Darowan S. ;

Wilson, Sharon L. ;

Shere-Wolfe, Kapana D. ;

Dakum, Paul ;

Charurat, Manhattan E. ;

Gilliam, Bruce L. .

CLINICAL INFECTIOUS DISEASES, 2013, 57 (09) :1300-1303

[3] Selection during cefepime treatment of a new cephalosporinase variant with extended-spectrum resistance to cefepime in an Enterobacter aerogenes clinical isolate [J].

Barnaud, G ;

Benzerara, Y ;

Gravisse, J ;

Raskine, L ;

Sanson-Le Pors, MJ ;

Labia, R ;

Arlet, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (03) :1040-1042

[4] Colistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections [J].

Bassetti, M. ;

Repetto, E. ;

Righi, E. ;

Boni, S. ;

Diverio, M. ;

Molinari, M. P. ;

Mussap, M. ;

Artioli, S. ;

Ansaldi, F. ;

Durando, P. ;

Orengo, G. ;

Pallavicini, F. Bobbio ;

Viscoli, C. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (02) :417-420

[5] Efficacy of ertapenem in the treatment of early ventilator-associated pneumonia caused by extended-spectrum β-lactamase-producing organisms in an intensive care unit [J].

Bassetti, Matteo ;

Righi, Elda ;

Fasce, Roberta ;

Molinari, Maria Pia ;

Rosso, Raffaella ;

Di Biagio, Antonio ;

Mussap, Michele ;

Pallavicini, Franco Bobbio ;

Viscoli, Claudio .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (02) :433-435

[6] 10 x '20 Progress-Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America [J].

Boucher, Helen W. ;

Talbot, George H. ;

Benjamin, Daniel K., Jr. ;

Bradley, John ;

Guidos, Robert J. ;

Jones, Ronald N. ;

Murray, Barbara E. ;

Bonomo, Robert A. ;

Gilbert, David .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (12) :1685-1694

[7] Clinical implications of inducible beta-lactamase activity in Gram-negative bacteremia in children [J].

Boyle, RJ ;

Curtis, N ;

Kelly, N ;

Garland, SM ;

Carapetis, JR .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (10) :935-939

[8] The Use of Systemic and Topical Fluoroquinolones [J].

Bradley, John S. ;

Jackson, Mary Anne .

PEDIATRICS, 2011, 128 (04) :E1034-E1045

[9] In Vivo Efficacy of Simulated Human Dosing Regimens of Prolonged-Infusion Doripenem against Carbapenemase-Producing Klebsiella pneumoniae [J].

Bulik, Catharine C. ;

Nicolau, David P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (10) :4112-4115

[10] Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: A multicenter, randomized study [J].

Chastre, Jean ;

Wunderink, Richard ;

Prokocimer, Philippe ;

Lee, Michael ;

Kaniga, Kone ;

Friedland, Ian .

CRITICAL CARE MEDICINE, 2008, 36 (04) :1089-1096

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