Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration

被引：214

作者：

Zammit, DJ ^{[1
]}

Turner, DL ^{[1
]}

Klonowski, KD ^{[1
]}

Lefrançois, L ^{[1
]}

Cauley, LS ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Immunol, Farmington, CT 06032 USA

来源：

IMMUNITY | 2006年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2006.01.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activated virus-specific CD8 T cells remain in the lung airways for several months after influenza virus infection. We show that maintenance of this cell population is dependent upon the route of infection and prolonged presentation of viral antigen in the draining lymph nodes (DLN) of the respiratory tract. The local effects on T cell migration have been examined. We show retention of virus-specific CD8 T cells in the mediastinal lymph node (MLN) and continuing recruitment of blood-borne migrants into the lung airways during antigen presentation. These data show that antigen that is retained after pulmonary influenza virus infection controls the migratory pattern and activation state of virus-specific CD8 T cells near the site of virus amplification.

引用

页码：439 / 449

页数：11

共 54 条

[1] Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy [J].

Aronsson, F ;

Lannebo, C ;

Paucar, M ;

Brask, J ;

Kristensson, K ;

Karlsson, H .

JOURNAL OF NEUROVIROLOGY, 2002, 8 (04) :353-357

[2]

Aronsson F, 2001, J NEUROVIROL, V7, P117

[3] Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract [J].

Chang, J ;

Braciale, TJ .

NATURE MEDICINE, 2002, 8 (01) :54-60

[4] Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells [J].

Dahl, ME ;

Dabbagh, K ;

Liggitt, D ;

Kim, S ;

Lewis, DB .

NATURE IMMUNOLOGY, 2004, 5 (03) :337-343

[5] IMMUNODOMINANCE OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RESTRICTED INFLUENZA-VIRUS EPITOPES CAN BE INFLUENCED BY THE T-CELL RECEPTOR REPERTOIRE [J].

DALY, K ;

NGUYEN, P ;

WOODLAND, DL ;

BLACKMAN, MA .

JOURNAL OF VIROLOGY, 1995, 69 (12) :7416-7422

[6] Establishment and persistence of virus-specific CD4(+) and CD8(+) T cell memory [J].

Doherty, PC ;

Topham, DJ ;

Tripp, RA .

IMMUNOLOGICAL REVIEWS, 1996, 150 :23-44

[7]

DONSKOY E, 1992, J IMMUNOL, V148, P1604

[8] Memory T cell populations in the lung airways are maintained by continual recruitment [J].

Ely, KH ;

Cookenham, T ;

Roberts, AD ;

Woodland, DL .

JOURNAL OF IMMUNOLOGY, 2006, 176 (01) :537-543

[9] Cutting edge:: Effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses [J].

Ely, KH ;

Roberts, AD ;

Woodland, DL .

JOURNAL OF IMMUNOLOGY, 2003, 171 (07) :3338-3342

[10] Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections [J].

Ely, KH ;

Cauley, LS ;

Roberts, AD ;

Brennan, JW ;

Cookenham, T ;

Woodland, DL .

JOURNAL OF IMMUNOLOGY, 2003, 170 (03) :1423-1429

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