Magnetic gold-nanorod/PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy

被引：116

作者：

Yang, Hung-Wei ^{[1
]}

Liu, Hao-Li ^{[2
]}

Li, Meng-Lin ^{[3
]}

Hsi, I-Wen ^{[2
]}

Fan, Chih-Tai ^{[3
]}

Huang, Chiung-Yin ^{[4
]}

Lu, Yu-Jen ^{[4
]}

Hua, Mu-Yi ^{[5
]}

Chou, Hsin-Yi ^{[2
]}

Liaw, Jiunn-Woei ^{[6
]}

Ma, Chen-Chi M. ^{[1
]}

Wei, Kuo-Chen ^{[4
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan

[2] Chang Gung Univ, Dept Elect Engn, Tao Yuan 33302, Taiwan

[3] Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 30013, Taiwan

[4] Chang Gung Mem Hosp, Dept Neurosurg, Tao Yuan 33305, Taiwan

[5] Chang Gong Univ, Dept Chem & Mat Engn, Tao Yuan 33302, Taiwan

[6] Chang Gong Univ, Dept Mech Engn, Tao Yuan 33302, Taiwan

来源：

BIOMATERIALS | 2013年 / 34卷 / 22期

关键词：

Magnetic gold nanorods; Photoacoustic microscopy; MRI; Photothermal therapy; Brain tumor; ENHANCED THERMAL-STABILITY; NANORODS; CELLS; SIZE; DOXORUBICIN; NANOSHELLS; ABLATION; PLATFORM; SHAPE; PPTT;

D O I：

10.1016/j.biomaterials.2013.03.085

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nanomedicine can provide a multi-functional platform for image-guided diagnosis and treatment of cancer. Although gold nanorods (GNRs) have been developed for photoacoustic (PA) imaging and near infra-red (NIR) photothermal applications, their efficiency has remained limited by low thermal stability. Here we present the synthesis, characterization, and functional evaluation of non-cytotoxic magnetic polymer-modified gold nanorods (MPGNRs), designed to act as dual magnetic resonance imaging (MRI) and PA imaging contrast agents. In addition, their high magnetization allowed MPGNRs to be actively localized and concentrated by targeting with an external magnet. Finally, MPGNRs significantly enhanced the NIR-laser-induced photothermal effect due to their increased thermal stability. MPGNRs thus provide a promising new theranostic platform for cancer diagnosis and treatment by combining dual MR/PA imaging with highly effective targeted photothermal therapy. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5651 / 5660

页数：10

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