Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer

被引：27

作者：

Yasuda, Yuichiro ^{[1
]}

Urata, Yoshiko ^{[1
]}

Tohnai, Rie ^{[1
]}

Ito, Shoichi ^{[1
]}

Kawa, Yoshitaka ^{[1
]}

Kono, Yuko ^{[1
]}

Hattori, Yoshihiro ^{[1
]}

Tsuda, Masahiro ^{[2
]}

Sakuma, Toshiko ^{[3
]}

Negoro, Shunichi ^{[1
]}

Satouchi, Miyako ^{[1
]}

机构：

[1] Hyogo Canc Ctr, Dept Thorac Oncol, Akashi, Hyogo, Japan

[2] Hyogo Canc Ctr, Dept Gastroenterol Oncol, Akashi, Hyogo, Japan

[3] Hyogo Canc Ctr, Dept Diagnost Pathol, Akashi, Hyogo, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 09期

关键词：

nivolumab; immune-related adverse event; colitis; non-small cell lung cancer; immune-checkpoint-inhibitor; MANAGEMENT; DOCETAXEL; BLOCKADE;

D O I：

10.2169/internalmedicine.9230-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose of nivolumab. A biopsy specimen of the colon mucosa revealed evidence of colitis with cryptitis and crypt microabscesses. He was diagnosed with immune-related colitis and started on predonisolone 60 mg/day. Subsequently, his symptoms remarkably resolved. Consideration of immune-related adverse events up to several years after the initiation of nivolumab is important.

引用

页码：1269 / 1272

页数：4

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