The Relationship Between Grey-Matter and ASD and ADHD Traits in Typical Adults

被引:32
|
作者
Geurts, Hilde M. [1 ,2 ]
Ridderinkhof, K. Richard [1 ,3 ,4 ]
Scholte, H. Steven [1 ]
机构
[1] Univ Amsterdam, Dept Psychol, NL-1018 XA Amsterdam, Netherlands
[2] Univ Amsterdam, Dept Psychol, ADHD & Autism Res Ctr Arc, NL-1018 XA Amsterdam, Netherlands
[3] Univ Amsterdam, Dept Psychol, Amsterdam Ctr Study Adapt Control Brain & Behav A, NL-1018 XA Amsterdam, Netherlands
[4] Univ Amsterdam, Cognit Sci Ctr Amsterdam CSCA, NL-1018 XA Amsterdam, Netherlands
关键词
ADHD; Autism; ASD; VBM; Grey-matter; sMRI; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDER; GRAY-MATTER; INHIBITORY CONTROL; METAANALYSIS; ACTIVATION; CHILDREN; ABNORMALITIES; POPULATION; PSYCHIATRY;
D O I
10.1007/s10803-012-1708-4
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
We tested whether in 85 healthy adults (18-29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities.
引用
收藏
页码:1630 / 1641
页数:12
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