Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice

被引：123

作者：

Olajide, OA ^{[1
]}

Makinde, JM ^{[1
]}

Awe, SO ^{[1
]}

机构：

[1] Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 66卷 / 01期

关键词：

Bridelia ferruginea; carrageenan-induced oedema; cotton pellet granuloma;

D O I：

10.1016/S0378-8741(99)00006-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The anti-inflammatory activity of the aqueous extract of the stem bark of Bridelia ferruginea was evaluated using carrageenan-induced paw oedema in rats and mice, and the cotton pellet granuloma method. The extract at doses ranging from 10 to 80 mg/kg p.o. significantly inhibited the carrageenan-induced rat paw oedema, with an ID50 value of 36 mg/kg. However, a low activity was produced in the mouse paw oedema. The extract also suppressed the granulomatous tissue formation of chronic inflammation. B. ferruginea therefore proved to be effective in both the acute and chronic phases of the inflammatory process. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 117

页数：5

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