Enzyme-Responsive Polymeric Supra-Amphiphiles Formed by the Complexation of Chitosan and ATP

被引：56

作者：

Kang, Yuetong ^{[1
]}

Wang, Chao ^{[1
]}

Liu, Kai ^{[1
]}

Wang, Zhiqiang ^{[1
]}

Zhang, Xi ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

来源：

LANGMUIR | 2012年 / 28卷 / 41期

关键词：

BUILDING-BLOCKS; NANOPARTICLES; RELEASE; SUPERAMPHIPHILES; OVEREXPRESSION; DEGRADATION; PARTICLES; PHENOTYPE;

D O I：

10.1021/la303271f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chitosan and adenosine-5'-triphosphate (ATP) are employed as building blocks to fabricate polymeric supra-amphiphiles based on electrostatic interactions, which can self-assemble to form spherical aggregates. The spherical aggregates inherit the phosphotase responsiveness of ATP. Compared to our previous work, this enzyme-responsive system can be more biocompatible and block polymers are not needed in preparation, which makes it possible to fabricate the chitosan-based enzyme-responsive assemblies in a large-scale, cheap way. Therefore, the application of the assemblies for nanocontainers and drug delivery is greatly anticipated.

引用

页码：14562 / 14566

页数：5

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