T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis

被引：48

作者：

Wang, S. ^{[1
]}

Baidoo, S. E. ^{[1
]}

Liu, Y. ^{[1
]}

Zhu, C. ^{[1
]}

Tian, J. ^{[1
]}

Ma, J. ^{[1
]}

Tong, J. ^{[1
]}

Chen, J. ^{[1
]}

Tang, X. ^{[1
]}

Xu, H. ^{[1
]}

Lu, L. ^{[2
]}

机构：

[1] Jiangsu Univ, Sch Med Sci & Lab Med, Affiliated Peoples Hosp, Dept Lab Med, Zhenjiang 212002, Jiangsu, Peoples R China

[2] Univ Hong Kong, Ctr Infect & Immunol, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2013年 / 171卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hashimoto's thyroiditis; leptin; Th17; cells; AUTOIMMUNE ENCEPHALOMYELITIS; INFLAMMATION; MICE; TH17; LYMPHOCYTES; STARVATION; RESPONSES; IMMUNITY; RECEPTOR; IL-23;

D O I：

10.1111/j.1365-2249.2012.04670.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the role of leptin and T helper type 17 (Th17) cells in Hashimoto's thyroiditis patients. Twenty-seven patients with Hashimoto's thyroiditis (HT) and 20 healthy controls were enrolled into the current study. A modest increase of plasma leptin in HT patients and the CD4+ T cell-derived leptin from HT patients was stronger than that from healthy controls. In HT patients, there are no statistically significant correlations between plasma leptin concentrations and the percentage of Th17 cells or the level of retinoic acid-related orphan receptor ?t (ROR?t), but strong positive correlations were observed between CD4+ T cell-derived leptin and the percentage of Th17 cells or the level of ROR?t mRNA, and additionally significantly up-regulated leptin, interleukin (IL)17 and ROR?t mRNA levels in the thyroid tissue. Furthermore, neutralization of leptin decreases the frequency of Th17 cells in vitro. Current study has revealed an increased leptin involvment in Hashimoto's thyroiditis associated with an increased number of Th17 cells.

引用

页码：63 / 68

页数：6

共 27 条

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