Family-based tests of association and/or linkage

被引:0
|
作者
Whittaker, JC
Morris, AP
机构
[1] Univ Reading, Dept Appl Stat, Reading RG6 6FN, Berks, England
[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX4 7BN, England
关键词
D O I
10.1046/j.1469-1809.2001.6550407.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The large literature on family-based tests of association and/or linkage is reviewed, concentrating on the underlying principles and on recent methodological developments. We explain the distinction between testing for association and testing for linkage, and give our views on the circumstances in which each is the appropriate null hypothesis.
引用
收藏
页码:407 / 419
页数:13
相关论文
共 50 条
  • [1] Family-based tests of association in the presence of linkage
    Lake, SL
    Blacker, D
    Laird, NM
    AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (06) : 1515 - 1525
  • [2] Family-based tests of association in the presence and absence of known linkage
    Bertram, L
    Hayward, B
    Lake, SL
    Falls, K
    Van Eerdewegh, P
    Blacker, D
    GENETIC EPIDEMIOLOGY, 2001, 21 : S292 - S297
  • [3] The TDT and other family-based tests for linkage disequilibrium and association
    Spielman, RS
    Ewens, WJ
    AMERICAN JOURNAL OF HUMAN GENETICS, 1996, 59 (05) : 983 - 989
  • [4] Accounting for linkage in family-based tests of association with missing parental genotypes
    Martin, ER
    Bass, MP
    Hauser, ER
    Kaplan, NL
    AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (05) : 1016 - 1026
  • [5] Interpretation of simultaneous linkage and family-based association tests in genome screens
    Chung, Ren-Hua
    Hauser, Elizabeth R.
    Martin, Eden R.
    GENETIC EPIDEMIOLOGY, 2007, 31 (02) : 134 - 142
  • [6] Family-based association tests
    Baur, MP
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1998, 81 (06): : 460 - 460
  • [7] Linkage, case-control association, and family-based association tests for complex disorders
    Brian K Suarez
    Robert Culverhouse
    Carol H Jin
    Anthony Hinrichs
    BMC Proceedings, 1 (Suppl 1)
  • [8] Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions
    Lunetta, KL
    Faraone, SV
    Biederman, J
    Laird, NM
    AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (02) : 605 - 614
  • [9] Power of family-based association tests
    Nsengimana, J
    Bishop, T
    Barrett, JH
    ANNALS OF HUMAN GENETICS, 2005, 69 : 771 - 771
  • [10] Family-Based Methods for Linkage and Association Analysis
    Laird, Nan M.
    Lange, Christoph
    GENETIC DISSECTION OF COMPLEX TRAITS, 2ND EDITION, 2008, 60 : 219 - 252