Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy) methyl) azetidine hydrochloride on β-amyloid-induced microglial activation

We aimed to assess the anti-inflammatory and antioxidative properties of KHG26792, a novel azetidine derivative, in amyloid beta (A beta)-treated primary microglial cells. KHG26792 attenuated the A beta-induced production of inflammatory mediators such as IL-6, IL-1 beta, TNF-alpha, and nitric oxide. The levels of protein oxidation, lipid peroxidation, ROS, and NADHP oxidase enhanced by A beta were also downregulated by KHG26792 treatment. The effects of KHG26792 against the A beta-induced increases in inflammatory cytokine levels and oxidative stress were achieved by increasing the phosphorylation of Akt/GSK-3 beta signaling and by decreasing the A.-induced translocation of NF-kappa B. Our results provide novel insights into the use of KHG26792 as a potential agent against A beta toxicity, including its role in the reduction of inflammation and oxidative stress. Nevertheless, further investigations of cellular signaling are required to clarify the in vivo effects of KHG26792 against A beta-induced toxicity.