Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study

被引：22
|
作者：
Allu, Suryanarayana [1 ]
Suresh, Kuthuru [1 ,3 ]
Bolla, Geetha [1 ]
Mannava, M. K. Chaitanya [1 ]
Nangia, Ashwini [1 ,2 ,3 ]
机构：
[1] Univ Hyderabad, Sch Chem, Prof CR Rao Rd,Gachibowli Cent Univ PO, Hyderabad 500046, Telangana, India
[2] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
[3] Univ Hyderabad, Technol Business Incubator, Prof CR Rao Rd,Cent Univ PO, Hyderabad 500046, Telangana, India
来源：
CRYSTENGCOMM | 2019年 / 21卷 / 13期
关键词：
PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHONS; PHYSICAL-PROPERTIES; DESIGN; DISPERSION; DRUGS; FORMS;
D O I：
10.1039/c8ce01075g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The stronger sulfonamide-pyridine (SO2NH2 center dot center dot center dot N-Py) and sulfonamide-carboxamide (SO2NH2 center dot center dot center dot O = C-NH) hydrogen bonds direct the formation of cocrystals, while the weaker sulfonamide-amine (SO2NH2 center dot center dot center dot N-H) hydrogen bond results in coamorphous products. IDP-PIP and IDP-ARG coamorphous solids exhibit remarkable stability under accelerated conditions.
引用
收藏
页码：2043 / 2048
页数：6
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