Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study

被引：22

作者：

Allu, Suryanarayana ^{[1
]}

Suresh, Kuthuru ^{[1
,3
]}

Bolla, Geetha ^{[1
]}

Mannava, M. K. Chaitanya ^{[1
]}

Nangia, Ashwini ^{[1
,2
,3
]}

机构：

[1] Univ Hyderabad, Sch Chem, Prof CR Rao Rd,Gachibowli Cent Univ PO, Hyderabad 500046, Telangana, India

[2] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

[3] Univ Hyderabad, Technol Business Incubator, Prof CR Rao Rd,Cent Univ PO, Hyderabad 500046, Telangana, India

来源：

CRYSTENGCOMM | 2019年 / 21卷 / 13期

关键词：

PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHONS; PHYSICAL-PROPERTIES; DESIGN; DISPERSION; DRUGS; FORMS;

D O I：

10.1039/c8ce01075g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The stronger sulfonamide-pyridine (SO2NH2 center dot center dot center dot N-Py) and sulfonamide-carboxamide (SO2NH2 center dot center dot center dot O = C-NH) hydrogen bonds direct the formation of cocrystals, while the weaker sulfonamide-amine (SO2NH2 center dot center dot center dot N-H) hydrogen bond results in coamorphous products. IDP-PIP and IDP-ARG coamorphous solids exhibit remarkable stability under accelerated conditions.

引用

页码：2043 / 2048

页数：6

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