Anti-inflammatory property of Kalpaamruthaa on myocardium in type 2 diabetes mellitus induced cardiovascular complication

被引：13
作者：
Raja, Latha [1 ]
Palanivelu, Shanthi [2 ]
Panchanatham, Sachdanandam [1 ]
机构：
[1] Univ Madras, Dept Med Biochem, Dr ALM Postgrad Inst Basic Med Sci, Madras 600113, Tamil Nadu, India
[2] Univ Madras, Dept Pathol, Dr ALM Postgrad Inst Basic Med Sci, Madras 600113, Tamil Nadu, India
来源：
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2013年 / 35卷 / 01期
关键词：
Type 2 diabetes mellitus; cardiovascular disease; inflammation; Kalpaamruthaa; C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; EMBLICA-OFFICINALIS; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; TNF-ALPHA; GLUCOSE; INFLAMMATION; CYCLOOXYGENASE-2;
D O I：
10.3109/08923973.2012.712138
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Efficacy of Kalpaamruthaa (KA) on the modulation of inflammatory markers in cardiovascular disease (CVD) induced by type 2 diabetes mellitus in experimental rats has been investigated in this study. Oxidative stress in hyperglycemia develops CVD by increasing the inflammatory markers. Administration of KA reduced the blood glucose level towards baseline in rats with diabetes induced CVD. Plasma C-reactive protein was elevated in CVD, while its level was markedly reduced upon KA treatment. Inducible nitric oxide synthase and cycloxygenase-2 expressions in immunoblots, interleukin-1 beta and interleukin-6 expressions in reverse transcriptase polymerase chain reaction and immunohistochemical expressions of tumor necrosis factor-a and nuclear factor-kappa B were increased in CVD-induced rats. KA renders its protection by decreasing these inflammatory markers in CVD-induced rats. Histochemical analysis of mast cell was studied. KA treated rats showed reduced count of mast cell in CVD-induced rat myocardium. This study provides the evidence of cardiovascular protective effect of KA in type 2 diabetes mellitus through its anti-inflammatory property.
引用
收藏
页码：119 / 125
页数：7
相关论文
共 40 条
[1]   Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals [J].
Aggarwal, Bharat B. .
ANNUAL REVIEW OF NUTRITION, VOL 30, 2010, 30 :173-199
[2]   Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages [J].
Baker, CSR ;
Hall, RJC ;
Evans, TJ ;
Pomerance, A ;
Maclouf, J ;
Creminon, C ;
Yacoub, MH ;
Polak, JM .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (03) :646-655
[3]   INDUCTION OF INFLAMMATORY CYTOKINE RELEASE FROM CULTURED HUMAN MONOCYTES BY C-REACTIVE PROTEIN [J].
BALLOU, SP ;
LOZANSKI, G .
CYTOKINE, 1992, 4 (05) :361-368
[4]   Diabetes-associated sustained activation of the transcription factor nuclear factor-κB [J].
Bierhaus, A ;
Schiekofer, S ;
Schwaninger, M ;
Andrassy, M ;
Humpert, PM ;
Chen, J ;
Hong, M ;
Luther, T ;
Henle, T ;
Klöting, I ;
Morcos, M ;
Hofmann, M ;
Tritschler, H ;
Weigle, B ;
Kasper, M ;
Smith, M ;
Perry, G ;
Schmidt, AM ;
Stern, DM ;
Häring, HU ;
Schleicher, E ;
Nawroth, PP .
DIABETES, 2001, 50 (12) :2792-2808
[5]   Novel clinical markers of vascular wall inflammation [J].
Blake, GJ ;
Ridker, PM .
CIRCULATION RESEARCH, 2001, 89 (09) :763-771
[6]   INTERACTION OF FLAVONOIDS WITH ASCORBATE AND DETERMINATION OF THEIR UNIVALENT REDOX POTENTIALS - A PULSE-RADIOLYSIS STUDY [J].
BORS, W ;
MICHEL, C ;
SCHIKORA, S .
FREE RADICAL BIOLOGY AND MEDICINE, 1995, 19 (01) :45-52
[7]   The cellular fate of glucose and its relevance in type 2 diabetes [J].
Bouché, C ;
Serdy, S ;
Kahn, CR ;
Goldfine, AB .
ENDOCRINE REVIEWS, 2004, 25 (05) :807-830
[8]   Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited [J].
Ceriello, A ;
Motz, E .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (05) :816-823
[9]   NF-κB:: pivotal mediator or innocent bystander in atherogenesis? [J].
Collins, T ;
Cybulsky, MI .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :255-264
[10]   C-REACTIVE PROTEIN IN PREGNANCY AND CONTRACEPTION [J].
CONNELL, EB ;
CONNELL, JT .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1971, 110 (05) :633-+
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