Eudragit® and hydrotalcite-like anionic clay composite system for diclofenac colonic delivery

被引：45

作者：

Ambrogi, V. ^{[1
]}

Perioli, L. ^{[2
]}

Ricci, M. ^{[1
]}

Pulcini, L. ^{[1
]}

Nocchetti, M. ^{[2
]}

Giovagnoli, S. ^{[1
]}

Rossi, C. ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim & Tecnol Farm, I-06123 Perugia, Italy

[2] Univ Perugia, Dipartimento Chim, I-06123 Perugia, Italy

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2008年 / 115卷 / 03期

关键词：

hydrotalcite-like anionic clays; diclofenac; composite system; colonic delivery; Eudragite;

D O I：

10.1016/j.micromeso.2008.02.014

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, the microencapsulation of the MgAl-hydrotalcite (HTlc) and diclofenac (DIK) intercalation product (HT]c-DIK) was realized in order to obtain a composite system for colonic drug delivery. Eudragite (R) S or Eudragit (R) L were used as polymers for preparation of microparticles (MPs). MPs were prepared by using a properly modified oil-in-oil solvent evaporation method. A 1:5 or 1:10 w/w HTlc-DIK/polymer ratios were employed. An experimental design was applied in order to assess the preparation variable effects oil the qualitative MP appearance. Improved MP preparations were achieved when 7-13 ml of acetone-ethanol solution was employed at both HTlc-DIK/polymer ratios. The MPs were tested for in vitro drug release. DIK release from Eudragite L MPs at pH 6.8 reached 26-35X, within 25-30 min at both HTlc-DIK/polymer ratios and no further increase was observed when the pH was shifted to 7.5. DIK release from Eudragite S MPs at pH 7.5 reached for both ratios 70%, after 6-8 h. The obtained results showed that hydrotalcite intercalation compound call be microencapsulated without missing the intercalated compound and the resulted composite MPs showed good characteristics. Besides HTlc-DIK/Eudragit (R) S MPs possess improved features with respect to HTlc-DIK/Eudragit (R) L MPs. For this reason, HTlc-DIK/Eudragit (R) S MPs could be promising for drug delivery either to the distal part of small intestine or to the colon. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：405 / 415

页数：11

共 17 条

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