The structures of type I polyketide synthases

被引：251
|
作者：
Keatinge-Clay, Adrian T. [1 ]
机构：
[1] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA
来源：
NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 10期
关键词：
FATTY-ACID SYNTHASE; 6-DEOXYERYTHRONOLIDE B SYNTHASE; CARRIER PROTEIN TRANSACYLASE; PEROXISOMAL MULTIFUNCTIONAL ENZYME; SECONDARY-METABOLITE BIOSYNTHESIS; CYANOBACTERIUM LYNGBYA-MAJUSCULA; ISOLATED KETOREDUCTASE DOMAINS; BETA-KETOACYL SYNTHASE; ACTIVE-SITE OCCUPANCY; CRYSTAL-STRUCTURE;
D O I：
10.1039/c2np20019h
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the domains but also the mysteries that remain to be solved.
引用
收藏
页码：1050 / 1073
页数：24
相关论文
共 50 条
  • [31] Type I polyketide synthases may have evolved through horizontal gene transfer
    Ginolhac, A
    Jarrin, C
    Robe, P
    Perrière, G
    Vogel, T
    Simonet, P
    Nalin, R
    JOURNAL OF MOLECULAR EVOLUTION, 2005, 60 (06) : 716 - 725
  • [32] Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming
    Wang, Jialiang
    Deng, Zixin
    Liang, Jingdan
    Wang, Zhijun
    NATURAL PRODUCT REPORTS, 2023, 40 (09) : 1498 - 1520
  • [33] Domain identification within fungal Type I polyketide synthases and its practical applications
    Couch, RD
    FASEB JOURNAL, 1999, 13 (07): : A1394 - A1394
  • [34] Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer
    Aurélien Ginolhac
    Cyrille Jarrin
    Patrick Robe
    Guy Perrière
    Timothy M. Vogel
    Pascal Simonet
    Renaud Nalin
    Journal of Molecular Evolution, 2005, 60 : 716 - 725
  • [35] An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases
    Kim, BS
    Sherman, DH
    Reynolds, KA
    PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (03): : 277 - 284
  • [36] Comments on the distribution and phylogeny of type I polyketide synthases and nonribosomal peptide synthetases in eukaryotes
    Sasso, Severin
    Shelest, Ekaterina
    Hoffmeister, Dirk
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (38) : E3946 - E3946
  • [37] The Use of PCR for Detecting Genes That Encode Type I Polyketide Synthases in Genomes of Actinomycetes
    B. E. Ostash
    S. V. Ogonyan
    A. N. Luzhetskyy
    A. Bechthold
    V. A. Fedorenko
    Russian Journal of Genetics, 2005, 41 : 473 - 478
  • [38] PKMiner: a database for exploring type II polyketide synthases
    Kim, Jinki
    Yi, Gwan-Su
    BMC MICROBIOLOGY, 2012, 12
  • [39] Evolutionary Histories of Type III Polyketide Synthases in Fungi
    Navarro-Munoz, Jorge Carlos
    Collemare, Jerome
    FRONTIERS IN MICROBIOLOGY, 2020, 10
  • [40] Type III polyketide synthases in natural product biosynthesis
    Yu, Dayu
    Xu, Fuchao
    Zeng, Jia
    Zhan, Jixun
    IUBMB LIFE, 2012, 64 (04) : 285 - 295
12345