The structures of type I polyketide synthases

被引：261

作者：

Keatinge-Clay, Adrian T. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 10期

关键词：

FATTY-ACID SYNTHASE; 6-DEOXYERYTHRONOLIDE B SYNTHASE; CARRIER PROTEIN TRANSACYLASE; PEROXISOMAL MULTIFUNCTIONAL ENZYME; SECONDARY-METABOLITE BIOSYNTHESIS; CYANOBACTERIUM LYNGBYA-MAJUSCULA; ISOLATED KETOREDUCTASE DOMAINS; BETA-KETOACYL SYNTHASE; ACTIVE-SITE OCCUPANCY; CRYSTAL-STRUCTURE;

D O I：

10.1039/c2np20019h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the domains but also the mysteries that remain to be solved.

引用

页码：1050 / 1073

页数：24

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